BiochemistrybioRxivPreprint
Determinants of spliceostatin reactivity at a spliceosomal zinc finger
Riccardo Rozza, Angela Parise, Jana Aupič…·Alessandra Magistrato
This study identifies the molecular mechanism by which spliceostatin binds and inhibits the SF3b complex, revealing the role of ZnCys4 coordination and proton relay in covalent bond formation.
DOI 10.1101/2025.09.17.676740