Jana Aupič

The paper resolves the mechanism of GTP hydrolysis in the RhoGAP-RhoA complex, revealing a tautomerization-driven process involving Gln63.

This study identifies the molecular mechanism by which spliceostatin binds and inhibits the SF3b complex, revealing the role of ZnCys4 coordination and proton relay in covalent bond formation.

This study uses cryo-EM and molecular dynamics simulations to reveal structural flexibility in the human vault protein, identifying conformational states and dynamic assembly mechanisms.

This study defines the mechanism by which METTL6 and SerRS cooperatively recognize and catalyze tRNA m3C methylation using simulations and in vitro experiments.

This study uses all-atom simulations to reveal that guanine in RNA has the strongest interaction with membranes, while base pairing reduces membrane binding.

This paper designs stable coiled-coil peptides for cellular regulation and detects SARS-CoV-2 spike protein-mediated cell fusion.