Author

Farzaneh Sadat Mirfakhar

Nova Southeastern UniversityORCID 0000-0002-8392-7244Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:imaging· 1

Frequent Co-Authors

Celeste M M. KarchiD· 1 shared Cláudia Guimas AlmeidaiD· 1 shared David H. PerlmutteriD· 1 shared Gary A. SilvermaniD· 1 shared Jacob A. MarshiD· 1 shared Jorge CastanheiraiD· 1 shared Jose Silva RamalhoiD· 1 shared Miguel MinayaiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Celeste M M. KarchORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 30, 2024

Autophagic enhancer rescues Tau accumulation in a stem cell model of frontotemporal dementia

Farzaneh Sadat Mirfakhar, Jacob A. Marsh, Miguel Minaya…·Celeste M M. Karch

This study shows that a mutation in the MAPT gene disrupts autophagy in neurons, leading to Tau accumulation, and that an autophagy enhancer drug reduces Tau levels.

1 citation

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NeurosciencebioRxivPreprintAug 31, 2023

The Alzheimer's disease risk gene CD2AP functions in dendritic spines by remodelling F-actin

Farzaneh Sadat Mirfakhar, Jorge Castanheira, Raquel Domingues…·Cláudia Guimas Almeida

This study shows CD2AP regulates dendritic spine morphology and synapse formation by modulating F-actin dynamics, linking its risk variants to Alzheimer's disease synaptic dysfunction.

DOI 10.1101/2023.08.31.555707

humanexperimental assay

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