Author

Paula M. Darwin

University of AberdeenORCID 0000-0002-8408-4680Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Alice P. SowtoniD· 2 shared Andrew J. MurrayiD· 2 shared Benjamin D. Thackray· 2 shared Julian Leether GriffiniD· 2 shared Lorenz M.W. HolzneriD· 2 shared Alice E. KnaptoniD· 1 shared Anna Cochrane· 1 shared Areesha NazeeriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

Alice P. SowtonORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintMay 5, 2026

Hepatic HIF2α modulates extra-hepatic disease-associated phenotypes during metabolic dysfunction-associated steatotic liver disease

Lorenz M.W. Holzner, Rosa M. Korpershoek, Youguo Niu…·Andrew J. Murray

This study investigates the role of hepatic HIF2α in MASLD, finding that its deletion leads to extra-hepatic complications like cardiac dysfunction and lean mass loss without protecting against liver disease progression.

DOI 10.64898/2026.04.02.716074

mouseexperimental assay

PhysiologyAmerican Journal of Physiology-Endocrinology and MetabolismPeer-reviewedDec 9, 2024

Chronic inorganic nitrate supplementation does not improve metabolic health and worsens disease progression in mice with diet-induced obesity.

Alice P. Sowton, Lorenz M.W. Holzner, Fynn N. Krause…·Andrew J. Murray

This study shows that chronic nitrate supplementation in mice with diet-induced obesity worsens metabolic health and accelerates disease progression, including liver cancer.

6 citations

mousebulk RNA-seq