Upregulated Ca2+ release from the endoplasmic reticulum leads to impaired presynaptic function in Alzheimer's disease
Temitope Adeoye, Syed Islamuddin Shah, Angelo Demuro, David A. Rabson, Ghanim Ullah
This study uses a biophysical model of hippocampal synapses to show that enhanced ER Ca2+ release in Alzheimer's disease increases neurotransmitter release probability and short-term plasticity, while causing depression and desynchronization during prolonged stimulation.
bioRxiv · Apr 21, 2022 · PreprintNeuroscience