Temitope Adeoye

This study models how amyloid beta pores disrupt synaptic function by altering calcium dynamics and interacting with ER dysfunction, revealing temporal patterns of synaptic hyperactivation and hypoactivation.

The paper identifies gene co-expression modules driving pathway dysregulation in Alzheimer's disease using single-nucleus RNA-seq data from brain regions.

This study uses a biophysical model of hippocampal synapses to show that enhanced ER Ca2+ release in Alzheimer's disease increases neurotransmitter release probability and short-term plasticity, while causing depression and desynchronization during prolonged stimulation.