Ghanim Ullah

The paper functionally characterizes the Drosophila vesicular glutamate transporter DVGLUT and compares it to rat rVGLUT1, finding higher allosteric affinity and anion channel activity in flies.

The paper quantifies astrocytic sodium concentrations in mouse brain tissue and finds subcellular and cellular heterogeneity in [Na+] and NKA-mediated potassium uptake.

This study investigates the spatio-temporal dynamics of Na+ diffusion in dendrites of mouse CA1 pyramidal neurons using imaging and simulations, finding that normal diffusion rapidly clears local Na+ transients.

This study models how amyloid beta pores disrupt synaptic function by altering calcium dynamics and interacting with ER dysfunction, revealing temporal patterns of synaptic hyperactivation and hypoactivation.

DL-SCAN automates cell segmentation and analysis in fluorescence microscopy images, improving consistency and reducing user bias in ion dynamics studies.

This study shows that short metabolic failures cause lasting increases in glutamate release, while longer episodes lead to postsynaptic transmission failure in hippocampal neurons.

The paper identifies gene co-expression modules driving pathway dysregulation in Alzheimer's disease using single-nucleus RNA-seq data from brain regions.

This study uses a biophysical model of hippocampal synapses to show that enhanced ER Ca2+ release in Alzheimer's disease increases neurotransmitter release probability and short-term plasticity, while causing depression and desynchronization during prolonged stimulation.

This study identifies ultraslow Na+ fluctuations in neonatal hippocampal neurons and astrocytes, showing they are driven by GABAergic inhibition and vulnerable to hyperactivity.

The paper models glutamate and GABA homeostasis in the synaptic cleft to show how transporter isoforms, uptake compartments, and cleft morphology affect neurotransmitter concentrations and neuronal behavior.

CellSpecks automates the detection and analysis of ion channel activity in live cells, providing detailed kinetic data from high-throughput imaging experiments.

TraceSpecks automates noise removal and state quantification in patch-clamp and imaging data, providing accurate and detailed analysis of ion channel behavior.