Author

Lodewijk J.A. Toonen

Leiden University Medical CenterORCID 0000-0002-8414-7418Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Barry A. PepersiD· 1 shared Bas RöttgeringiD· 1 shared Chantal BeekmaniD· 1 shared Davy CatsiD· 1 shared Eleni MinaiD· 1 shared Elsa C. KuijperiD· 1 shared Hailiang MeiiD· 1 shared Janwillem TesterinkiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Barry A. PepersORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 22, 2026

VO659, a CAG repeat-targeting antisense oligonucleotide, lowers multiple neurotoxic mutant huntingtin proteins in Huntington's disease

Bas Röttgering, Rudie Weij, Suzanne Bijl…·Nicole A. Datson

VO659 reduces multiple neurotoxic mutant huntingtin proteins in Huntington's disease by targeting CAG repeats, while sparing wild-type HTT.

DOI 10.64898/2026.10.16.758452

humanexperimental assay

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GeneticsHuman Molecular GeneticsPeer-reviewedSep 23, 2025

Determining off-target effects of splice-switching antisense oligonucleotides using short read RNAseq in neuronally differentiated human induced pluripotent stem cells

Elsa C. Kuijper, Linda van der Graaf, Barry A. Pepers…·Willeke van Roon‐Mom

This study uses RNAseq to assess off-target effects of three splice-switching AONs in human cells, identifying splicing changes and showing variability in AON-induced effects.

5 citations

humanbulk RNA-seq

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