Broad influence of mutant ataxin-3 on the proteome of the adult brain, young neurons, and axons reveals central molecular processes and biomarkers in SCA3/MJD using knock-in mouse model
Kalina Wiatr, Łukasz Marczak, J. Pérot, Emmanuel Brouillet, Julien Flament, Maciej Figiel
This study investigates the molecular mechanisms of SCA3/MJD using a knock-in mouse model, revealing axonal dysfunction and altered protein localization as key features of the disease.
Frontiers in Molecular Neuroscience · Jun 17, 2021Peer-reviewedNeuroscience