Emmanuel Brouillet

Modeling Huntington disease against age-related genes reveals CXXC4 as an epigenetic target to restore DRD1 striatal neuron activity

The paper identifies CXXC4 as an epigenetic target that can restore DRD1 striatal neuron activity in Huntington disease by leveraging age-related gene patterns.

Reactive astrocytes promote proteostasis in Huntington disease through the JAK2-STAT3 pathway

This study shows that activating the JAK2-STAT3 pathway in astrocytes reduces mutant Huntingtin aggregates and improves disease outcomes in Huntington's disease models.

Identification of the key role of white matter alteration in the pathogenesis of Huntington's Disease

This study uses longitudinal MRI in a mouse model to show early white matter defects in Huntington's Disease, highlighting their role in pathogenesis and identifying potential biomarkers.

Broad influence of mutant ataxin-3 on the proteome of the adult brain, young neurons, and axons reveals central molecular processes and biomarkers in SCA3/MJD using knock-in mouse model

This study investigates the molecular mechanisms of SCA3/MJD using a knock-in mouse model, revealing axonal dysfunction and altered protein localization as key features of the disease.

Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease

This study investigates the role of reactive astrocytes in Alzheimer's disease by modulating the JAK2-STAT3 pathway in 3xTg-AD mice, finding no effect on Tau or amyloid pathology but behavioral changes.

Diffusion-weighted magnetic resonance spectroscopy enables cell-specific monitoring of astrocyte reactivity in vivo

This study uses diffusion-weighted magnetic resonance spectroscopy to detect astrocyte reactivity in mice by analyzing changes in myo-inositol diffusion linked to morphological alterations.