Julien Flament

This study evaluates AAV9-miR-ATXN3 in a non-human primate model of SCA3, showing reduced neuropathology through allele-specific silencing of mutant ATXN3.

This study shows that activating the JAK2-STAT3 pathway in astrocytes reduces mutant Huntingtin aggregates and improves disease outcomes in Huntington's disease models.

The paper maps glutamate distribution in adult and old primate brains using high-field gluCEST imaging, identifying age-related changes in specific brain regions and networks.

This study uses longitudinal MRI in a mouse model to show early white matter defects in Huntington's Disease, highlighting their role in pathogenesis and identifying potential biomarkers.

This study investigates the molecular mechanisms of SCA3/MJD using a knock-in mouse model, revealing axonal dysfunction and altered protein localization as key features of the disease.

This study uses diffusion-weighted magnetic resonance spectroscopy to detect astrocyte reactivity in mice by analyzing changes in myo-inositol diffusion linked to morphological alterations.