Author

Maciej Figiel

Institute of Bioorganic Chemistry, Polish Academy of SciencesORCID 0000-0003-3961-4635Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Bart KristiD· 2 shared Jakub KubiśiD· 2 shared Karolina Świtońska-KurkowskaiD· 2 shared Anna Samelak-CzajkaiD· 1 shared Emmanuel BrouilletiD· 1 shared J. PérotiD· 1 shared Jan PodkowińskiiD· 1 shared Joanna Delimata-RaczekiD· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersDevelopmental Biology

Bart KristORCID

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Author profile →

4 papers

Recent·Most cited

Early Neurodevelopmental Defects in Huntingtons Disease are Driven by Choroid Plexus Overgrowth and Altered Paracrine Signaling

Karolina Świtońska-Kurkowska, Jakub Kubiś, Joanna Delimata-Raczek, Bart Krist, Magda Surdyka, Żaneta Kalinowska-Pośka, Piotr Piasecki, Luiza Handschuh, Jan Podkowiński, Magdalena Rakoczy, Anna Samelak-Czajka, Michael R. Hayden, Nicholas S. Caron, Maciej Figiel

This study identifies early neurodevelopmental defects in juvenile-onset HD driven by choroid plexus overgrowth and altered paracrine signaling using organoid and mouse models.

bioRxiv · Sep 23, 2024 · PreprintDevelopmental Biology

The Cell Subtypes Selection by Genes (CSSG) algorithm for discovering cell populations in high resolution

Jakub Kubiś, Maciej Figiel

The paper introduces the CSSG algorithm and JSEQ pipeline to discover high-resolution cell populations and their relationships in tissues using transcriptomic data.

bioRxiv · Apr 20, 2023 · PreprintBioinformatics

Juvenile Huntington's Disease and Other PolyQ diseases, Update on Neurodevelopmental Character and Comparative Bioinformatic Review of Transcriptomic Data

Karolina Świtońska-Kurkowska, Bart Krist, Joanna Maria Delimata, Maciej Figiel

The paper reviews transcriptomic data from PolyQ diseases to identify neurodevelopmental expression patterns and compare disease-related pathways across different conditions.

Frontiers in Cell and Developmental Biology · Jul 1, 2021Peer-reviewedNeuroscience

Broad influence of mutant ataxin-3 on the proteome of the adult brain, young neurons, and axons reveals central molecular processes and biomarkers in SCA3/MJD using knock-in mouse model

Kalina Wiatr, Łukasz Marczak, J. Pérot, Emmanuel Brouillet, Julien Flament, Maciej Figiel

This study investigates the molecular mechanisms of SCA3/MJD using a knock-in mouse model, revealing axonal dysfunction and altered protein localization as key features of the disease.

Frontiers in Molecular Neuroscience · Jun 17, 2021Peer-reviewedNeuroscience