DiffDomain-Spectrum identifies structurally reorganized TADs from sparse aggregated single-cell Hi-C contact maps
Jiadi Zhu, Haishan Zhang, Yanyi Du, Xiao Zhang, Yan Zhou, Dechao Tian
DiffDomain-Spectrum identifies reorganized TADs from sparse aggregated scHi-C maps by analyzing eigenvalue spectra and comparing to a null model, showing higher sensitivity than existing methods.
bioRxiv · Sep 17, 2026 · PreprintGenetics