Yan Zhou

DiffDomain-Spectrum identifies reorganized TADs from sparse aggregated scHi-C maps by analyzing eigenvalue spectra and comparing to a null model, showing higher sensitivity than existing methods.

The paper develops EXACT, a framework combining ex vivo drug screening with transcriptomic analysis to identify effective drug combinations for rare cancers, finding a MEK and HDAC inhibitor combination shows enhanced activity.

This study identifies an enhancer of Ctnnb1 that regulates Wnt signaling dosage, maintaining intestinal homeostasis and suppressing colorectal cancer.

This paper shows that KDM2B suppresses Wnt signaling in neural progenitors to regulate hippocampal development and morphology.

This study maps the cellular diversity of the embryonic mouse coronal suture using single-cell transcriptomics, identifying key markers and cell types involved in suture development and fusion.

This study identifies CircGLCE as a regulator of intervertebral disc degeneration by modulating apoptosis and matrix degradation via miR-587/STAP1.

This study shows ADNP is essential for neural differentiation by maintaining Wnt/β-catenin signaling, and its disruption causes neural developmental defects in mice and zebrafish.

This study identifies LncKdm2b as a lncRNA that cis-activates Kdm2b to regulate cortical neuronal differentiation through chromatin remodeling.