Andrei T. Alexandrescu

High-pH NMR to Identify Macromolecular Hydrogen-Bonds and Foldons

This paper uses high-pH NMR to identify hydrogen bonds and foldons in proteins, achieving higher accuracy than traditional methods.

Solution Structure of the Novel CH-domain zinc finger from the puberty regulator Makorin-3

This paper determines the solution structure of the CH-domain zinc finger from Makorin-3, revealing its metal-binding properties and potential role in protein interactions.

Ant abaecin-2 is a context-dependent copper-binding effector that can be either inhibitory or protective

This paper characterizes abaecin-2, a hymenopteran HDP with copper-binding properties that can inhibit or protect bacteria depending on context.

Zinc-induced folding and solution structure of the eponymous novel zinc finger from the ZC4H2 protein

The paper investigates the zinc-induced folding and solution structure of the ZC4H2 zinc finger, showing it folds around zinc with picomolar affinity and has a novel structural motif.

Templated trimerization of the phage L decoration protein on capsids

This paper studies the trimerization of the phage L decoration protein, showing that capsid templating accelerates its folding and that the C-terminal spike is essential for capsid binding.

Solution structure of the Z0 domain from transcription repressor BCL11A sheds light on the sequence properties of protein-binding zinc-fingers

The paper determines the solution structure of the Z0 domain of BCL11A and identifies sequence patterns distinguishing DNA-binding from non-binding zinc-fingers.

Structural Model of Bacteriophage P22 Scaffolding Protein in a Procapsid by Magic-Angle Spinning NMR

This study determines the structure of bacteriophage P22 scaffolding protein within its procapsid using magic-angle spinning NMR, revealing a trimer of dimers with both helical and disordered regions.

Perturbations in mitochondrial metabolism associated with defective cardiolipin biosynthesis: An in-organello real-time NMR study

This study uses in-organello NMR to analyze how cardiolipin defects affect mitochondrial metabolism in yeast, showing altered metabolite kinetics and TCA cycle flux.

Formerly degenerate seventh zinc finger domain from transcription factor ZNF711 rehabilitated by experimental NMR structure

The paper shows that a previously thought non-functional zinc finger domain from ZNF711 can fold with three metal ligands and is catalytically active.

NMR structure verifies the eponymous degenerate zinc finger domain of transcription factor ZNF750

The paper uses NMR to show that the degenerate ZNF domain of ZNF750 binds Zn2+ with high affinity and forms a structured ββ fold, challenging the assumption that degenerate ZNFs are disordered.