Angela M. Gronenborn

Structural Basis of Second-Generation HIV-1 Maturation Inhibitor Activity by Magic Angle Spinning NMR

This study uses MAS NMR to determine the binding mode of HRF-4467, a second-generation HIV-1 maturation inhibitor, in the CA-SP1-NC11 complex with IP6, revealing its mechanism of action and resistance profile.

Rapidly evolving aphid gall effector proteins exhibit saposin-like folds

The paper predicts structures of rapidly evolving aphid effector proteins using Alphafold2 with custom multiple sequence alignments, revealing saposin-like folds and structural diversity.

Structural Basis for HIV-1 Maturation Inhibition by PF-46396 Determined by MAS NMR

This study determines the atomic structure of HIV-1 CACTD-SP1 assemblies with PF-46396 and IP6 using MAS NMR, revealing binding modes and IP6 dynamics.

Pushing Sensitivity and Specificity Limits in Native Structural Biology: 19F Multinuclear Dynamic Nuclear Polarization with Magic Angle Spinning

The paper introduces a 19F-based DNP MAS NMR method for atomic-level structural analysis of proteins in mammalian cells, demonstrating high sensitivity and specificity for detecting target proteins.

Cataract-prone variants of γD-crystallin populate a conformation with a partially unfolded N-terminal domain under native conditions

This study identifies a partially unfolded N-terminal domain intermediate in cataract-associated γD-crystallin variants under native conditions, revealing hydrophobic patches that may contribute to cataract formation.

Structural Model of Bacteriophage P22 Scaffolding Protein in a Procapsid by Magic-Angle Spinning NMR

This study determines the structure of bacteriophage P22 scaffolding protein within its procapsid using magic-angle spinning NMR, revealing a trimer of dimers with both helical and disordered regions.