Author

Nathan N. Alder

University of ConnecticutORCID 0000-0003-4474-7803Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:mechanistic / dynamical model· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:yeast· 1

Frequent Co-Authors

Adam ZweifachiD· 1 shared Andrei T. AlexandrescuiD· 1 shared Antonio J. RuaiD· 1 shared Benjamin T. Garrett· 1 shared Eric R. MayiD· 1 shared Jeffrey D. TamucciiD· 1 shared Joseph C. Iovine· 1 shared Steven Michael ClaypooliD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 10 mutual co-author links

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1 shared paperBiophysics

Adam ZweifachORCID

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3 papers

Recent·Most cited

BiophysicsLangmuirPeer-reviewedDec 4, 2025

Mitochondria-Targeted Peptides and Bilayer Composition Modulate Membrane Electro-poration Under Elevated Electrochemical Stress

Jeffrey D. Tamucci, Adam Zweifach, Nathan N. Alder, Eric R. May

The paper uses MD simulations to show that cardiolipin and a mitochondria-targeted peptide reduce electroporation risk by altering membrane capacitance and electrostatics under electrochemical stress.

1 citation

mechanistic / dynamical model

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Molecular BiologyBiochimica et Biophysica Acta (BBA) - BiomembranesPeer-reviewedOct 5, 2025

Lateral lipid packing governs bilayer solubilization by styrene-maleic acid copolymers: a case study with cardiolipin-containing membranes

Joseph C. Iovine, Benjamin T. Garrett, Nathan N. Alder

This study investigates how cardiolipin affects SMA copolymer-mediated membrane solubilization by examining lateral lipid packing effects.

2 citations

experimental assay

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BiophysicsJournal of Biological ChemistryPeer-reviewedSep 3, 2024

Perturbations in mitochondrial metabolism associated with defective cardiolipin biosynthesis: An in-organello real-time NMR study

Antonio J. Rua, Wayne Mitchell, Steven Michael Claypool…·Andrei T. Alexandrescu

This study uses in-organello NMR to analyze how cardiolipin defects affect mitochondrial metabolism in yeast, showing altered metabolite kinetics and TCA cycle flux.

6 citations

yeastmetabolomics

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