Focal Adhesion Kinase (FAK) inhibition induces membrane accumulation of aquaporin2 (AQP2) through endocytosis inhibition and actin depolymerization in renal epithelial cells.
Asma Tchakal-Mesbahi, Jinzhao He, Shuai Zhu, Ming Huang, Kazuhiko Fukushima, Richard Bouley, Dennis Brown, Hua A. Jenny Lu
This study shows FAK inhibition leads to AQP2 membrane accumulation by blocking endocytosis and causing actin depolymerization in renal cells.
American Journal of Physiology-Renal Physiology · Aug 26, 2025Peer-reviewedCell Biology