Shuhei A. Horiguchi

This study computationally designs layered tissue architectures by modulating cell-cell interfacial tension, showing how tension variations can generate structured multilayers and hierarchical organization.

The paper examines inner ear morphogenesis across 12 vertebrate species, finding that divergent mechanical processes in tissue expansion are coordinated with developmental tempo to maintain conserved morphology.

The paper shows antiparallel cell circulation arises from self-aligned polarity-dependent tension gradients in confluent tissues.

This study identifies a mechanism for epithelial stratification analogous to a phase transition, driven by foam-geometric instability and nucleation-growth processes.

The paper presents a theoretical framework for cell death by modeling it as a controllability problem in dynamical systems, using stoichiometric rays to define life-death boundaries.

A robotic AI system using Bayesian optimization accelerates iPSC-RPE cell differentiation, achieving 88% better pigmented scores than pre-optimized methods.