Aiko Sada

This study investigates the in vivo effects of St6gal1 and Man1a glycogenes on epidermal homeostasis in mice, finding distinct impacts on proliferation, inflammation, and glycosylation patterns.

This study shows fibulin 7 protects against skin inflammation by modulating IL-17A signaling in a psoriasis model.

The paper identifies G-CSF produced by skin endothelial cells as a driver of pathological granulopoiesis and neutrophil infiltration in psoriasis, offering a potential therapeutic target.

This study identifies Il1r2 as a marker for slow-cycling epidermal basal cells and develops a genetic tool for lineage tracing and IL-1 signaling modulation.

This study uses label-free Raman imaging to identify distinct cell populations in human skin, revealing molecular signatures associated with specific epidermal layers and stem cell niches.

This study shows that RUNX1-ETO expression in keratinocytes causes progressive skin inflammation through transcriptional dysregulation and activation of inflammatory pathways.

This study shows that fibulin-5 maintains epidermal stem cell heterogeneity during aging by regulating integrin expression and YAP signaling.

The paper shows that IL-1 signaling suppresses Wnt activity in epidermal stem cells during inflammation, leading to changes in stem cell compartments that can be reversed by Wnt reactivation.

This study shows that retinoic acid treatment shifts the balance between slow- and fast-cycling epidermal stem cells in mouse and human skin.

This study investigates how undulating tissue structures influence epithelial stem cell heterogeneity in skin and oral mucosa using mouse models and 3D culture systems.

This study identifies a mechanism for epithelial stratification analogous to a phase transition, driven by foam-geometric instability and nucleation-growth processes.

This study shows that fibulin 7 maintains epidermal stem cell heterogeneity during skin aging by preserving fast-cycling clones and preventing inflammation-related gene expression.

The paper identifies compartmentalized stem and progenitor populations in the ocular surface epithelium with distinct division frequencies using lineage tracing in mice.