Sonali Das

This paper identifies a biphasic regulatory loop where type 1 interferon initially enhances mitochondrial fatty acid oxidation (FAO) to amplify its own production, but excessive IFN signaling induces ISG15-mediated inhibition of FAO, creating a negative feedback loop to control inflammation.

The paper introduces SPICE, a pipeline for identifying composite DNA elements, and discovers novel JUN-IKZF1 interactions in the IL10 gene.