Author

Erin E. West

National Institutes of HealthORCID 0000-0002-7103-8394Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Claudia KemperiD· 2 shared Anand Kumar GuptaiD· 1 shared Behdad AfzaliiD· 1 shared Christian A. CombsiD· 1 shared Daniel Chauss· 1 shared Dhaneshwar KumariD· 1 shared Didier PortillaiD· 1 shared Ganne Ganne· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Claudia KemperORCID

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2 papers

Recent·Most cited

Intracellular complement Factor B couples inflammatory sensing to metabolism, chromatin regulation and maladaptive tissue repair

Tilo Freiwald, Daniel Chauss, Md Tajmul, Jorge L. Trujillo-Ochoa, Dhaneshwar Kumar, Jianping Ma, Madeline Snyder, Nardos Cheru, Julius FE Jaeger, Yuxin Zhuang, Justin B. Gregor, Ganne Ganne, Luopin Wang, Yubing Guo, Maja Gunkel, , Behdad Afzali

The paper identifies an injury-induced complement program in kidney cells that couples inflammation to metabolism and chromatin regulation, promoting maladaptive fibrosis.

bioRxiv · Oct 11, 2026 · PreprintImmunology

ISG15 orchestrates dynamic crosstalk between mitochondrial fat oxidation and type 1 interferon in myeloid cells

Anand Kumar Gupta, Jing Wu, Pijush K. Das, Rahul Sharma, Sonali Das, Kim Han, Rachael J. Klein, Rebecca D. Huffstutler, Christian A. Combs, Warren J. Leonard, Claudia Kemper, Erin E. West, Michael N. Sack

This paper identifies a biphasic regulatory loop where type 1 interferon initially enhances mitochondrial fatty acid oxidation (FAO) to amplify its own production, but excessive IFN signaling induces ISG15-mediated inhibition of FAO, creating a negative feedback loop to control inflammation.

bioRxiv · Jan 21, 2026 · PreprintImmunology