Reproductive history differentially shapes the neural response of middle-aged females to estradiol therapy after a metabolic challenge
Jennifer E. Richard, Ahmad Mohammad, Stephanie E. Lieblich…·Liisa A.M. Galea
This study shows that reproductive history and APOE genotype influence how middle-aged females respond to estradiol therapy and metabolic stress, with primiparous hAPOE4 females showing increased inflammation and memory impairment.