Liisa A.M. Galea

This study shows that female sex and APOEe4 genotype differentially affect microglial transcriptomic profiles in the hippocampus and cortex of mice.

The paper maps cellular and molecular changes in the mouse brain during pregnancy and postpartum using spatial single-cell technologies, identifying three gene expression programs and linking depression risk genes to specific brain regions.

This study evaluates sex inclusion in Nature articles in 2025, finding that while most include both sexes, many do so nominally and lack meaningful sex analysis.

This study shows that reproductive history and APOE genotype influence how middle-aged females respond to estradiol therapy and metabolic stress, with primiparous hAPOE4 females showing increased inflammation and memory impairment.

This study examines how parity and APOEε4 genotype affect functional connectivity and cognitive outcomes in middle-aged rats.

The paper examines how parity and age affect hippocampal cell types in rats, finding age is the dominant factor, while parity independently impacts specific cell populations.

This study examines the sex-specific metabolic and cognitive effects of GLP-1 estradiol conjugate in middle-aged rats on standard or Western diets, showing differential impacts on weight, cytokines, and neurogenesis.

The paper identifies sex-dependent impairments in parvalbumin interneurons in the retrosplenial cortex as a cause of cognitive deficits in Alzheimer's disease and suggests targeting these neurons as a therapeutic strategy.

This study shows estradiol and estrone differentially affect neurogenesis in adult female rats' dentate gyrus, with short-term effects but not long-term.

This study examines how maternal age at first pregnancy and estradiol treatment affect hippocampal neuroplasticity, inflammation, and spatial memory in middle-aged rats.

This study examines how menstrual cycle phases affect resting-state brain connectivity in healthy females, finding distinct patterns in causal connectivity linked to hormone levels.

The paper investigates how APOEε4 genotype interacts with parity to affect neuroplasticity and neuroinflammation in middle-aged female rats.

This study examines long-term effects of pregnancy on brain cellular and molecular changes in rats, finding increased synaptic proteins and altered aging trajectories.

This study shows that aerobic training improves cognitive performance and neurogenesis in middle-aged mice, with effects influenced by sex and BDNF Val66Met genotype.

This study examines sex differences in fear memory, new neuron activation, and functional connectivity in the limbic system using rats.

The paper examines sex differences in brain-age-gap estimates using neuroimaging data from the Human Connectome Project, finding sex-specific patterns in regional brain ageing and predictors of global brainAGE.

The paper examines sex and age differences in cognitive bias and neural activation in rats, finding greater negative bias in adults and sex-specific neural activation patterns.

The paper examines sex differences and estradiol effects on MAPK and Akt signaling in hippocampal subregions, finding higher Akt phosphoproteins in intact females and estradiol-induced changes in ovariectomized females.

This paper assesses changes in sex inclusion and analysis in neuroscience and psychiatry research from 2009 to 2019, finding limited progress in incorporating sex as a key variable despite increased reporting of both sexes.

This study examines how postpartum corticosterone and fluoxetine affect the tryptophan-kynurenine pathway in dams, showing increased neurotoxic metabolites and limited SSRI efficacy.

This study examines how sex and APOE genotype influence inflammatory biomarkers in Alzheimer's disease using CSF and plasma data from the ADNI database.

This study investigates sex differences and the effects of gonadal hormones and amphetamine on risk-based decision making in rats using a probabilistic discounting task.

This study shows male rats have faster maturation and greater attrition of adult-born neurons in the hippocampus compared to females, highlighting sex differences in neurogenesis.

This study investigates the effects of postpartum fluoxetine on maternal neuroinflammation and tryptophan metabolism in a rodent model of postpartum depression, finding increased hippocampal IL-1β and reduced plasma tryptophan levels.

This study examines the sex-specific effects of oxytocin on social behavior and hypothalamic oxytocin cells in adult rats, finding no effect on hippocampal neurogenesis.

This study investigates how estrogen receptor α and β activation affects depressive-like behaviors in female mice under chronic stress and non-stress conditions.

This study shows that long-term ovariectomy alters neuroinflammatory responses and behavioral outcomes to sub-chronic stress in middle-aged mice, highlighting the role of ovarian hormones in stress-related disorders.