Stephanie E. Lieblich

Reproductive history differentially shapes the neural response of middle-aged females to estradiol therapy after a metabolic challenge

This study shows that reproductive history and APOE genotype influence how middle-aged females respond to estradiol therapy and metabolic stress, with primiparous hAPOE4 females showing increased inflammation and memory impairment.

Parity and APOEε4 genotype contribute distinct changes to functional connectivity across the middle-aged brain

This study examines how parity and APOEε4 genotype affect functional connectivity and cognitive outcomes in middle-aged rats.

Sex-Specific Metabolic and Central Effects of GLP-1 Estradiol Conjugate in Middle-Aged Rats on a Standard or Western Diet

This study examines the sex-specific metabolic and cognitive effects of GLP-1 estradiol conjugate in middle-aged rats on standard or Western diets, showing differential impacts on weight, cytokines, and neurogenesis.

Pregnancy History and Estradiol Influence Spatial Memory, Hippocampal Plasticity, and Inflammation in Middle-aged Rats

This study examines how maternal age at first pregnancy and estradiol treatment affect hippocampal neuroplasticity, inflammation, and spatial memory in middle-aged rats.

High Estradiol reduces adult neurogenesis but strengthens functional connectivity within the hippocampus during spatial pattern separation in adult female rats

Exploring the parity paradox: Differential effects on neuroplasticity and neuroinflammation by APOEe4 genotype at middle-age

The paper investigates how APOEε4 genotype interacts with parity to affect neuroplasticity and neuroinflammation in middle-aged female rats.

Long-term cellular and molecular signatures of pregnancy in the adult and ageing brain

This study examines long-term effects of pregnancy on brain cellular and molecular changes in rats, finding increased synaptic proteins and altered aging trajectories.

Sex and BDNF Val66Met Polymorphism matter for exercise-induced increase in neurogenesis and cognition in middle-aged mice

This study shows that aerobic training improves cognitive performance and neurogenesis in middle-aged mice, with effects influenced by sex and BDNF Val66Met genotype.

Risk-based Decision Making in Rats: Modulation by Sex and Amphetamine

This study investigates sex differences and the effects of gonadal hormones and amphetamine on risk-based decision making in rats using a probabilistic discounting task.

Oxytocin has sex-specific effects on social behaviour and hypothalamic oxytocin immunoreactive cells but not hippocampal neurogenesis in adult rats.

This study examines the sex-specific effects of oxytocin on social behavior and hypothalamic oxytocin cells in adult rats, finding no effect on hippocampal neurogenesis.

Selective activation of estrogen receptors α and β: Implications for depressive-like phenotypes in female mice exposed to chronic unpredictable stress

This study investigates how estrogen receptor α and β activation affects depressive-like behaviors in female mice under chronic stress and non-stress conditions.

Ovarian hormone status dictates the neuroinflammatory and behavioural consequences of sub-chronic stress exposure in middle-aged female mice

This study shows that long-term ovariectomy alters neuroinflammatory responses and behavioral outcomes to sub-chronic stress in middle-aged mice, highlighting the role of ovarian hormones in stress-related disorders.

Androgens enhance adult hippocampal neurogenesis in males but not females in an age-dependent manner

This study shows that dihydrotestosterone increases new neuron survival in young male rats but not in middle-aged males or females.

Early and Late Effects of Maternal Experience on Hippocampal Neurogenesis, Microglia, and the Circulating Cytokine Milieu

This study examines how motherhood affects hippocampal neurogenesis, microglia, and cytokines in rats, finding both short-term and long-term changes related to aging and cognition.

Premarin has opposing effects on spatial learning, neural activation and serum cytokine levels in middle age dependent on reproductive history

This study shows that Premarin affects spatial learning, neuronal activation, and cytokine levels differently in middle-aged rats based on their reproductive history.