Supratim Datta

Surface Binding Sites Orchestrate Long-Range Control of Active-Site Dynamics and Glucose Tolerance in β-glucosidase, BglB

This study identifies surface secondary binding sites in β-glucosidase BglB that regulate glucose inhibition and catalytic activity through long-range structural and energetic changes.

Engineering a Glucose-Inducible Whole-Cell Biosensor via CRISPRi-Based Promoter Reprogramming

This paper develops a CRISPRi-based glucose-inducible biosensor in E. coli that converts native glucose repression into a tunable fluorescent output, with high specificity and sensitivity for glucose monitoring.

A Highly Thermostable and Novel GH5 Endoglucanase from Bacillus sp. Strain BS with Enhanced Biomass Saccharification Potential in Seawater

This paper identifies a novel thermostable GH5 endoglucanase from Bacillus sp. strain BS that efficiently hydrolyzes cellulose and functions in seawater, reducing freshwater use in biofuel production.

Domain Compatibility and Linker Design Dictate the Success of Chimeric Cellulase Engineering

This study designs chimeric cellulases by combining endoglucanases and β-glucosidases, finding that domain compatibility and linker design are critical for maintaining catalytic activity and stability.

Reprogrammed E. coli for secretion of thermophilic cellulase cocktail for seawater-compatible lignocellulosic bioprocessing

This paper engineers E. coli to secrete a thermophilic cellulase cocktail that functions in seawater, achieving high yields and activity for lignocellulosic bioprocessing.