Sustained Interleukin-1β overexpression exacerbates Tau pathology in a murine tauopathy model via cyclooxygenase-1
Simantini Ghosh, Solomon S. Shaftel, Stephanos Kyrkanides, John A. Olschowka, M. Kerry O’Banion
This study shows that sustained IL-1β overexpression worsens tau pathology in mice via COX-1, and COX-1 inhibition reduces phospho-tau and glial activation.
bioRxiv · Feb 10, 2021 · PreprintNeuroscience