Global repression of mesenchymal genes in epithelial cells by the histone demethylase LSD1
Robert E Turnbull, Oksana Gonchar, Kristupas Sirvydis, Mariam Iftikhar, Megan E Coulson, So Yeon Kwon, James T Hodgkinson, Paul Badenhorst, Shaun M Cowley, John WR Schwabe
This study shows LSD1 represses mesenchymal genes in epithelial cells, maintaining epithelial identity, and challenges the therapeutic use of LSD1 inhibition for EMT control.
bioRxiv · Nov 6, 2026 · PreprintMolecular Biology