Shaun M. Cowley

This study shows LSD1 represses mesenchymal genes in epithelial cells, maintaining epithelial identity, and challenges the therapeutic use of LSD1 inhibition for EMT control.

The paper identifies molecular determinants of HDAC1 complex assembly through mutations, showing that specific residues are critical for complex binding and gene regulation.

This study identifies primary targets of individual class I HDAC complexes and shows that their rapid degradation leads to gene regulation with significant specificity and antagonistic effects.

This study rapidly degrades HDAC1 in ESCs to show its dual role in gene repression and active transcription by modulating histone acetylation at promoters and enhancers.

The paper shows HDACs maintain pluripotency by regulating RNA polymerase II recruitment to enhancer regions through histone acetylation and BRD4 interactions.