John W. R. Schwabe

This study shows LSD1 represses mesenchymal genes in epithelial cells, maintaining epithelial identity, and challenges the therapeutic use of LSD1 inhibition for EMT control.

This study investigates how heme binds to BACH1's CP motifs and how this affects DNA dissociation, revealing that multiple residues contribute to heme binding and DNA release.

The paper identifies molecular determinants of HDAC1 complex assembly through mutations, showing that specific residues are critical for complex binding and gene regulation.

This study identifies primary targets of individual class I HDAC complexes and shows that their rapid degradation leads to gene regulation with significant specificity and antagonistic effects.

This paper introduces an engineered sortase, cW11, for modifying and isolating histone H3 tails to study epigenetic modifications and their effects on enzyme processing and protein recognition.

This study identifies damaging LXRα mutations linked to reduced triglycerides but increased liver enzyme levels and hepatotoxicity, suggesting LXR's role in liver health and cautioning against its inhibition for MASLD treatment.