Vittorio Sebastiano

This study uses single-cell transcriptomics to identify gene regulatory networks and lineage trajectories in human fetal thymic epithelial cells, revealing interferon response pathways that distinguish thymic epithelium from other anterior foregut-derived organs.

The paper develops an in vitro protocol to generate human Pharyngeal Endoderm cells and uses multi-omics analysis to reveal Retinoic Acid's role in their epigenetic and transcriptional development.

The paper identifies PRC2 low-methylated regions as a universal biomarker of aging and rejuvenation, showing they account for most age-related DNA methylation gain across tissues.

The paper identifies TERT-positive multi-lineage precursor cells in human blastocysts using single-cell expression profiling of HPAT lincRNAs.