Katja Gabriele Weinacht

Adrenomedullin Restores Mitochondrial Bioenergetics and Rescues Interneuron Phenotypes in Human Models of 22q11.2 Deletion Syndrome

This study identifies mitochondrial dysfunction in 22q11.2DS interneurons and shows that Adrenomedullin rescues these defects through distinct signaling pathways.

Development in context: interferon response networks regulate human fetal thymic epithelial cell differentiation

This study uses single-cell transcriptomics to identify gene regulatory networks and lineage trajectories in human fetal thymic epithelial cells, revealing interferon response pathways that distinguish thymic epithelium from other anterior foregut-derived organs.

Multi-omics analysis reveals a crucial role for Retinoic Acid in promoting epigenetic and transcriptional competence of an in vitro model of human Pharyngeal Endoderm.

The paper develops an in vitro protocol to generate human Pharyngeal Endoderm cells and uses multi-omics analysis to reveal Retinoic Acid's role in their epigenetic and transcriptional development.