Liangdan Sun

A non-coding variant at 2p24.2 confers susceptibility to non-syndromic cleft lip and palate through LLPS-dependent regulation of MYCN

This study identifies a non-coding variant at 2p24.2 that increases susceptibility to NSCLP by disrupting FOXP2-mediated LLPS and impairing MYCN transcriptional activation.

Sequencing of the MHC region defines HLA-DQA1 as the major independent risk for anti-citrullinated protein antibodies (ACPA)-positive rheumatoid arthritis in Han population

This study identifies HLA-DQA1 as the major independent genetic risk for ACPA-positive RA in Han population through MHC region sequencing and HLA-typing.