Xu Liu

Co-targeting KRAS and BCL-2 induces pyroptosis and antitumor tertiary lymphoid structures

This study shows that combining KRAS and BCL-2 inhibition induces pyroptosis and tertiary lymphoid structures in KRAS G12D-mutant lung cancer, enhancing B-cell-dependent antitumor immunity.

A direct, MFRN-independent Fe(II) transfer pathway at mitochondria-lysosome contacts

The paper identifies a direct, MFRN-independent Fe(II) transfer pathway at mitochondria-lysosome contacts, bypassing the cytosolic labile iron pool.

GCN-Mamba: Graph Convolutional Network with Mamba for Antibacterial Synergy Prediction

GCN-Mamba predicts antibacterial synergies by combining graph convolutional networks and Mamba models, outperforming classical methods and validating novel combinations in vitro.

MtDNA heteroplasmy controls tumor immune reprogramming through mitochondrial translation

The paper shows that mtDNA heteroplasmy regulates tumor progression by modulating mitochondrial translation and immune microenvironment remodeling through the LARS2-S100A8/A9 axis.

Sequencing of the MHC region defines HLA-DQA1 as the major independent risk for anti-citrullinated protein antibodies (ACPA)-positive rheumatoid arthritis in Han population

This study identifies HLA-DQA1 as the major independent genetic risk for ACPA-positive RA in Han population through MHC region sequencing and HLA-typing.