Biomolecular tracking by FIRESCAPE reveals distinct modes of clearance, damage induction and cellular uptake for extracellular histone H3
Brian Josephson, Adeline W. J. Poh, Yana Demyanenko, Abi G. Yates, Joseph Ford, Andrew M. Giltrap, Tatsiana Auchynnikava, Kel Vin Tan, Isobel K. Dunstan, Weibing Liu, Adam P. Cribbs, Chenyi Wang, Martin Philpott, Sarah Able, Jeroen B. I. Sap, , Benjamin G. Davis
This paper introduces FIRESCAPE, a radiolabeling method to study extracellular histone H3 clearance and effects, revealing distinct behaviors compared to intact nucleosomes.
bioRxiv · Aug 13, 2025 · PreprintBiochemistry