Alex M. Dickens

This study identifies Cn-alkylpyrones as endogenous agonists for GPR84, linking fatty acid biosynthesis derailment to pro-inflammatory signaling through KR inhibition.

This study shows that early-life PFAS exposure causes sex-dependent metabolic changes in plasma and brain of mice, with females showing more extensive alterations.

The paper develops a UHPLC-MS/MS assay to quantify 21 steroids in plasma, adipose tissue, and fecal samples with high sensitivity and accuracy.

This study links gut transit time, inferred from stool consistency, to microbial metabolites and microbiota in infants, showing associations with breastfeeding, bile acid metabolism, and short-chain fatty acids.

This study uses multimodal metabolic analysis to detect early metabolic changes in acute neuroinflammation, showing reduced pyruvate metabolism and ongoing inflammation without structural MRI changes.

This study examines how human milk metabolites relate to the infant gut microbiome and metabolome over time, finding time-dependent associations and differential influences based on dietary changes.

This study examines the metabolic effects and biotransformation of F6H8 in human hepatocytes, revealing concentration-dependent metabolic alterations and the formation of a PFAS-like biotransformation product.

This study evaluates the pharmacokinetics and efficacy of tank-water administered dabrafenib in zebrafish with BRAF-mutant melanoma, showing rapid absorption, short half-life, and effective treatment with minimal toxicity.

This study transfers exuberant toddler gut microbiota to rats, increasing their exploratory behavior without affecting locomotion or social behavior.

The paper uses a colon simulator to study microbial lipid shifts in the gut and validates findings using human samples.

This paper introduces FIRESCAPE, a radiolabeling method to study extracellular histone H3 clearance and effects, revealing distinct behaviors compared to intact nucleosomes.

This paper introduces a method to track neurodegeneration biomarkers using PET imaging with isosteric protein mimics, revealing spinal fluid dynamics and neuronal loss mechanisms.

The paper investigates the relationship between central CB1-receptor availability and peripheral endocannabinoids in first-episode psychosis patients and healthy controls, finding dysregulated cross-talk between these systems.

This study examines how prenatal exposure to PFAS affects neonatal serum phospholipids and increases the risk of type 1 diabetes in offspring.

The paper identifies metabolic patterns in PBMCs associated with progression to islet autoimmunity and T1D using longitudinal metabolomics and metabolic modeling.