Li Sun

Dissecting the Contribution of Transposable Elements to Interphase Chromosome Structure

This study shows transposable elements contribute significantly to 3D genome structure by mediating chromatin contacts through specific transcription factors.

BRD8 guards the pluripotent state by sensing and maintaining histone acetylation

This study shows BRD8 maintains pluripotency by sensing and maintaining histone acetylation, preventing the conversion of primed EpiSCs to naive ESCs.

Integrated temporal profiling of iPSCs-derived motor neurons from ALS patients carrying C9orf72, FUS, TARDBP, and SOD1 mutations

This study profiles temporal RNA-seq in iPSC-derived motor neurons from ALS patients with specific mutations, identifying shared gene expression and splicing defects across different mutations.

Human embryos arrest in a quiescent-like state characterized by metabolic and zygotic genome activation problems

This study identifies a quiescent-like state in arrested IVF embryos and shows that modulating metabolic pathways can rescue the arrest.

Unveiling transposable element expression heterogeneity in cell fate regulation at the single-cell level

The paper develops a single-cell TE analysis pipeline, scTE, and shows TEs are dynamically expressed in various cell states and can be used for cell type discrimination.

Transposable Element-Gene Splicing Modulates the Transcriptional Landscape of Human Pluripotent Stem Cells

This study shows that transposable elements contribute to the transcriptome of human pluripotent stem cells by being spliced into coding and non-coding transcripts, affecting gene expression and generating novel peptides.