Melissa Boneta Davis

Mutant p53 Directs PARP to Regulate Replication Stress and Drive Breast Cancer Metastasis

This study shows mutant p53 uses its C-terminal domain to reprogram PARP activity, enabling replication stress adaptation and metastasis in TNBC, and identifies mtp53 as a biomarker for PARP inhibitor and DNA-damaging therapy.

An explainable boosting machine model for identifying artifacts caused by formalin-fixed paraffin embedding

This paper introduces an explainable boosting machine model to identify and filter variant artifacts caused by formalin-fixed paraffin embedding in cancer genomics.

African Pan Genome Contigs Expose Biologically Relevant Sequence Still Hidden from Human Reference Frameworks

The paper identifies African Pan Genome contigs that are missing from current human reference genomes, showing they contain functionally relevant sequences and are enriched in African ancestry.

Pan-Cancer PDOs Preserve Tumor Heterogeneity and Uncover Therapeutic Vulnerabilities

This study develops a pan-cancer PDO platform to preserve tumor heterogeneity and identify therapeutic vulnerabilities, finding that 58% of PDOs respond to Talazoparib and combination screens reveal resistance-overcoming drugs.

Whole Exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry

This study analyzes whole-exome sequencing data from Nigerian prostate cancer tumors to identify germline and somatic variants associated with African ancestry and DNA repair gene mutations.