Pharmacology & ToxicologybioRxivPreprint
Integrating Literature Evidence to Enhance CRISPR-based Target Screening for Hand-foot Syndrome
Qiqi Yang, Bingxue Yang, Junkang An…·Shiyi Zhang
This paper introduces a dual-filter strategy combining literature-mined targets with CRISPR/Cas9 screening to prioritize credible drug targets for hand-foot syndrome, identifying ATF4 as a key regulator and forskolin as a potential therapeutic.
DOI 10.1101/2025.03.09.642163