Author
Howard Hughes Medical InstituteORCID 0000-0003-0694-219XUnclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Ryan Moreira, Constantin Giurgiu, Imran R. Rahman…·Wilfred A. van der Donk
The paper presents the first high-resolution structure of two interacting lanthipeptides and shows how they disrupt cell membranes.
Chandrashekhar Padhi, Lingyang Zhu, Jeff Y. Chen…·Wilfred A. van der Donk
This study identifies a conserved FHAFRF-motif in precursor peptides of MNIO-encoding BGCs and demonstrates that MNIO and B12-rSAM enzymes catalyze ortho-hydroxylation and crosslinking of phenylalanine residues to form macrocyclic peptides.
Ryan Moreira, Yi Yang, Youran Luo…·Wilfred A. van der Donk
This paper identifies bibacillin 1, a two-component lantibiotic from Bacillus thuringiensis, showing cooperative bactericidal activity and distinct mechanism of action compared to other lantibiotics.