Murat Tuğrul

Stochastic Biophysics of Cellular Radiosensitivity: From Molecular Noise and Repair Kinetics to Evolutionary Demographics

The paper develops a stochastic framework to model DNA damage and repair kinetics, linking single-cell stochasticity to population-level radiosensitivity and tumor recurrence.

Protein aggregation drives cell aging in a size-specific manner in Escherichia coli

This study shows that protein aggregation in E. coli drives aging by reducing intracellular space, leading to larger cell sizes and asymmetric divisions.

Population Consequences of Single-Cell Damage Dynamics: An Overlooked Role of Mortality Under Stress

The paper investigates how single-cell damage dynamics under stress affect population fitness, finding that damage-dependent mortality is a key factor.

Optimal division asymmetry in E. coli bacteria

The paper shows that division asymmetry in E. coli has evolved to an optimum for population growth, with selective forces primarily acting on transcription signal asymmetry variance.