Joshua N. Johnstone

Quantifying Somatic Mutation Burden: An Assay Validation Framework and Implementation in SomaticCODEC

The paper introduces a framework for validating somatic mutation burden assays using relative validation and secondary metrics, implemented in SomaticCODEC with strong linearity and precision in human samples.

Transiently restricting individual amino acids protects D. melanogaster against multiple stressors

The paper shows that restricting individual amino acids, particularly isoleucine, in Drosophila melanogaster increases resistance to multiple stressors, including nicotine, oxidative stress, and cold shock.

GCN2 mediates access to stored amino acids for somatic maintenance during Drosophila ageing

This study shows GCN2-mediated autophagy allows Drosophila to use stored amino acids for somatic maintenance during dietary deprivation, extending lifespan.