Matthew D. W. Piper

The paper measures age-related organ system decline in 19 Drosophila lines to show genetic variation in physiological decline patterns across genotypes.

The paper develops a flexible diet platform for nutrigenomic screening in Drosophila disease models, showing it can identify nutrient-specific effects on disease phenotypes.

This study shows dietary zinc and protein-to-carbohydrate ratio interact to regulate reproduction and lifespan in Drosophila, with Zn having effects comparable to macronutrient adjustments.

This study shows that low sterol diets in Drosophila melanogaster females lead to gut dysfunction and reduced lifespan.

This study shows that dietary zinc limitation in Drosophila affects reproduction without reducing lifespan, highlighting its role in resource allocation between fitness traits.

This study establishes a Drosophila model of ECHS1 deficiency and shows that valine restriction improves larval survival.

The paper shows that restricting individual amino acids, particularly isoleucine, in Drosophila melanogaster increases resistance to multiple stressors, including nicotine, oxidative stress, and cold shock.

This paper introduces an adjusted diet formula for Drosophila melanogaster larvae to improve growth, development, and survival, with applications in studying metabolic disorders.

This study shows GCN2-mediated autophagy allows Drosophila to use stored amino acids for somatic maintenance during dietary deprivation, extending lifespan.

The paper investigates how different essential amino acids affect egg production in Drosophila when depleted, finding that methionine and histidine have distinct impacts compared to other amino acids.

The study updates exome matching to account for protein size and expression, finding that differential gene expression between sexes does not improve fecundity, suggesting conserved amino acid proportions across taxa.

The paper shows that restricting a single amino acid in Drosophila increases survival during nicotine exposure through mTORC1 and GCN2 signaling pathways.

VideoTagger enables efficient annotation of long video experiments, demonstrating its utility in analyzing Drosophila aging by identifying age-related mobility changes.

This paper identifies GATA transcription factors that regulate the effects of dietary restriction and TOR signaling on lifespan in Drosophila, showing tissue-specific manipulation can decouple longevity from fitness costs.