Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution
Laura M. Bartos, Sabrina Viktoria Kirchleitner, Zeynep Ilgin Kolabas, Stefanie Quach, Alexander Beck, Julia Lorenz, Jens Blobner, Stephan A. Müller, Selin Ulukaya, Luciano Hoeher, Izabela Horvath, Karin Wind-Mark, Adrien Holzgreve, Viktoria Ruf, Lukas Gold, , Matthias Brendel
The paper identifies cellular sources of PET signals in glioblastoma by combining radiotracer uptake with 3D-histology and proteomics, showing tumor cells mainly contribute to TSPO enrichment while TAMs have specific PET targets.
Science Advances · Oct 27, 2023Peer-reviewedNeuroscience