Luciano Hoeher

DISCO-seq enables 3D single-cell transcriptomics of whole tissues and organisms by combining tissue-clearing chemistry with imaging and transcriptomic profiling.

LipiGo is a DNA-lipid nanoparticle hybrid that enables efficient delivery of functional mRNA to non-hepatic tissues, particularly the spleen, through passive redistribution and active targeting.

This paper introduces MouseMapper, a deep learning tool combined with 3D imaging to analyze whole-body structural changes in obesity, revealing nerve and immune system alterations.

DELiVR uses VR-generated data to train deep learning models for quantifying c-Fos in cleared mouse brains, revealing new activation patterns in cancer-related brain activity.

The paper identifies cellular sources of PET signals in glioblastoma by combining radiotracer uptake with 3D-histology and proteomics, showing tumor cells mainly contribute to TSPO enrichment while TAMs have specific PET targets.