Jürgen A. Ripperger

Region specific Per1 induction dissociates circadian and mood responses to light

The paper shows that light's effects on circadian rhythms and mood are mediated by distinct Per1 pathways in the SCN and LHb, respectively.

Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock

This study shows that Cdk5 activity, modulated by light, gates rapid circadian phase shifts by regulating calcium influx and signaling pathways in SCN neurons.

CDK5 influences the organization of the Circadian Machinery in peripheral clocks.

This study shows CDK5 regulates peripheral circadian clocks by affecting their period, gene expression amplitude, and phase in mouse cells.

Light affects behavioral despair involving the clock gene Period 1

The paper shows light affects mood-related behaviors in mice by inducing the clock gene Per1 in the lateral habenula, altering gene expression in the mesolimbic dopaminergic system.

Deletion of the Clock Gene Period2 (Per2) in Glial Cells Alters Mood-Related Behavior in Mice

This study shows that deleting Per2 in glial cells of mice alters mood-related behaviors, reducing despair and anxiety with changes in neurotransmitter levels.

Cyclin Dependent Kinase 5 (CDK5) Regulates the Circadian Clock

This study identifies CDK5 as a kinase that regulates the mammalian circadian clock by phosphorylating PER2, facilitating its nuclear entry and maintaining circadian period.