Ian Robert Winship

Bidirectional chemogenetic modulation of claustral activity causes altered cortical dynamics

This study shows that modulating claustral activity in mice alters cortical dynamics, with inhibition increasing activity in anterior-medial regions and excitation decreasing it.

Aberrant cortical activity, functional connectivity, and neural assembly architecture after photothrombotic stroke in mice

This study uses in vivo two-photon calcium imaging in awake mice to track cortical activity and network changes after photothrombotic stroke, revealing localized and long-lasting disruptions in neural function and connectivity.

Pleiotrophin signals through ALK receptor to enhance growth of neurons in the presence of inhibitory CSPGs

This study shows that pleiotrophin (PTN) promotes neurite outgrowth in neurons exposed to inhibitory CSPG matrix via ALK receptor activation.

Distinct patterns of activity in individual cortical neurons and local networks in primary somatosensory cortex of mice evoked by mechanical limb stimulation

The paper uses two-photon calcium imaging to analyze how neurons in the somatosensory cortex of mice respond to mechanical limb stimulation at different frequencies, revealing stimulus-specific activation patterns and frequency-dependent network correlations.

Inflammatory cytokine profile and plasticity of brain and spinal microglia in response to ATP and glutamate

The paper compares the response of spinal cord and brain microglia to ATP and glutamate under physiologically relevant conditions and shows that these DAMPs do not significantly modulate cytokine release, but environmental factors can alter microglial inflammatory responses.