Mikaela Hukkanen

An epigenetic palimpsest: the King penguin's blood methylome reveals conserved hematopoietic ageing

This study identifies conserved ageing-associated genes in King penguins using methylome data and shows their relevance to human epigenetic age prediction.

The BEAC, an epigenetic clock for birds

The paper develops BEAC, an epigenetic clock for birds, validated across multiple species and showing strong predictive performance for chronological age.

The effects of early-life ambient temperature on the gut microbiome of a wild bird? an experimental approach

This study examines how subtle temperature changes during early life affect gut microbiome diversity and composition in wild birds, finding that rearing environment has a greater influence than genetics.

Predicting Alzheimer's disease phenotypes with aging clocks: an exploratory analysis

This study explores proteomic and epigenetic aging clocks as biomarkers for Alzheimer's disease phenotypes, finding proteomic clocks improve explained variance in cognitive and biomarker measures by up to 18%.

Sedentary life accelerates epigenetic ageing in King penguins

This study shows that sedentary life in zoo-housed King penguins accelerates epigenetic ageing, similar to humans, linked to methylation changes in metabolic and heart-related pathways.

Human reproduction comes at the expense of faster aging and a shorter life

This study finds that early childbearing, numerous pregnancies, and nulliparity are associated with accelerated aging and increased mortality risk in Finnish twin women.

Expression of m6A RNA methylation markers in the hypothalamus of Atlantic salmon

The paper investigates m6A RNA methylation gene expression in Atlantic salmon hypothalamus, finding differential expression of m6A reader and eraser genes associated with sexual maturation timing.

Altricial bird early-stage embryos express the molecular "machinery" to respond to maternal thyroid hormone cues

The paper shows that early-stage altricial bird embryos express genes involved in thyroid hormone pathways, suggesting they can respond to maternal thyroid hormone signals.