Neonatal Platelets Differentiate Monocytes to a Myeloid Derived Suppressor Cell Phenotype
Preeti Maurya, Daniel P. O’Reilly, Zachary T. Hilt, Alison C. Livada, Kathleen E. McGrath, Chen Li, Sara K. Ture, Michael W. Malloy, Ei Thanda Tun, James Palis, Craig N. Morrell
This study shows neonatal platelets induce monocytes to a Myeloid Derived Suppressor Cell phenotype, limiting T-cell activation, which may explain adverse outcomes of platelet transfusions in neonates.
Blood · Apr 16, 2026Peer-reviewedImmunology