An adaptor for feedback regulation of heme biosynthesis by the mitochondrial protease CLPXP
Thomas Cottle, Lydia Joh, Cori Posner, Adam DeCosta, Dean R. Campagna, Mark D. Fleming, Sarah Ducamp, Julia R. Kardon
The paper identifies POLDIP2 as a heme-sensing adaptor that facilitates CLPXP-mediated degradation of ALAS, elucidating the mechanism of heme-induced feedback regulation in heme biosynthesis.
Science · Jul 30, 2026Peer-reviewedBiochemistry